The Eugene L. Opie Collection spans much of his medical career. It contains lecture notes as well as research and autopsy notes. Opie took extensive notes on lectures he attended while a student at the Johns Hopkins University School of Medicine from 1894 to 1897. These notes are in four volumes: 1)Bacteriology and Pathology, 2) Pathology, 3)Medicine Surgery, and 4) Obstetrics. The lecturers include William Osler, William Halsted, Howard A. Kelly, William H. Welch, William S. Thayer, Simon Flexner, John Whitridge Williams, and Thomas S. Cullen. The two volumes of autopsy notes (1895-1908) mainly concern diabetes and pancreatic pathology. They are indexed by patient number. Another volume of notes is labeled Diabetes; these appear to be notes on published experiments. An undated manuscript, Adoption of Standards of the Best Medical Schools of Western Europe by Those of the United States includes photographs and concerns the history of the medical schools of St. Louis, Missouri. The text discusses Opie's appointment and refers to other individuals at the Washington University School of Medicine with ties to Johns Hopkins. There is also correspondence (1954-1955) with Alan M. Chesney.