The Wade Hampton Frost Collection spans most of his career. It contains administrative records, correspondence, drafts of papers and lectures on epidemiology, research material, photographs, and biographical material, including posthumous tributes. Research material includes notes and data on tuberculosis, typhoid, influenza, measles, diphtheria, scarlet fever, and polio. Correspondence includes the American Red Cross, the U.S. Public Health Service, and the Surgeon General. The collection is a resource for studying early twentieth-century epidemiology and the development of the department of epidemiology at the Johns Hopkins University School of Hygiene and Public Health.