The B. Frank Polk Collection consists of Polk’s teaching and course files, correspondence, committee files, research materials, and publications relating to his work as a faculty member at The Johns Hopkins University School of Public Health in the Department of Epidemiology and at the School of Medicine in the Departments of Medicine and Gynecology and Obstetrics. The papers document the leadership role Polk played as part of the effort at the Johns Hopkins Medical Institutions to prioritize, understand, and treat patients with AIDS in the years following the appearance of the disease. Polk was active in the creation of an AIDS Treatment Unit at the Johns Hopkins Hospital. The collection includes Polk’s research files in Obstetrics and Gynecology and his research on AIDS transmission and treatment. It includes records pertaining to a longitudinal AIDS Study, MACS, the Multicenter AIDS Cohort Study. Polk was the principle investigator for SHARE (Study to Help the AIDS Research Effort), the Baltimore arm of the MACS study. The collection contains an extensive set of reprints of articles co-authored by Polk.